{"product_id":"enzo-biochem-17-dmag-us","title":"Enzo Biochem 17-DMAG","description":"\u003carticle class=\"wlb-product\" itemscope itemtype=\"https:\/\/schema.org\/Product\"\u003e\n\u003cheader class=\"wlb-header\"\u003e\n\u003ch2 class=\"wlb-title\" itemprop=\"name\"\u003eEnzo Biochem 17-DMAG\u003c\/h2\u003e\n\u003cp class=\"wlb-meta\"\u003eby \u003cspan class=\"wlb-brand\" itemprop=\"brand\"\u003eEnzo Biochem\u003c\/span\u003e · SKU \u003cspan class=\"wlb-sku\" itemprop=\"sku\"\u003eALX-380-101\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/header\u003e\n\u003csection class=\"wlb-overview\"\u003e\n\u003ch2\u003eOverview\u003c\/h2\u003e\n\u003cp\u003e17-DMAG (17-dimethylaminoethylamino-17-demethoxygeldanamycin) is a semi-synthetic derivative of the antibiotic geldanamycin. It functions as a potent, water-soluble inhibitor of Heat Shock Protein 90 (Hsp90), exhibiting higher bioavailability and reduced hepatotoxicity compared to its parent compound.\u003c\/p\u003e\n\u003c\/section\u003e\n\u003csection class=\"wlb-highlights\"\u003e\n\u003ch2\u003eHighlights\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003ePotent Hsp90 inhibition with high water solubility for versatile experimental buffer compatibility.\u003c\/li\u003e\n\u003cli\u003eEnhanced metabolic stability and lower toxicity profile than 17-AAG.\u003c\/li\u003e\n\u003cli\u003eMaintains high affinity for the ATP-binding pocket of Hsp90, disrupting the stabilization of oncogenic client proteins.\u003c\/li\u003e\n\u003cli\u003eProven efficacy in modulating cellular stress response pathways in vitro.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/section\u003e\n\u003csection class=\"wlb-ataglance\"\u003e\n\u003ch2\u003eAt-a-glance\u003c\/h2\u003e\n\u003cdl\u003e\n\u003cdt\u003eCAS\u003c\/dt\u003e\n\u003cdd\u003e467214-20-6\u003c\/dd\u003e\n\u003cdt\u003eFormula\u003c\/dt\u003e\n\u003cdd\u003eC32H48N4O8\u003c\/dd\u003e\n\u003cdt\u003eMolecular Weight\u003c\/dt\u003e\n\u003cdd\u003e616.8 g\/mol\u003c\/dd\u003e\n\u003cdt\u003ePurity\u003c\/dt\u003e\n\u003cdd\u003e≥98% (HPLC)\u003c\/dd\u003e\n\u003cdt\u003eForm\u003c\/dt\u003e\n\u003cdd\u003eLyophilized powder or solid\u003c\/dd\u003e\n\u003cdt\u003eRecommended Applications\u003c\/dt\u003e\n\u003cdd\u003eCancer research, proteomics, heat shock protein mapping, cell signaling inhibition.\u003c\/dd\u003e\n\u003cdt\u003eCompatibility\u003c\/dt\u003e\n\u003cdd\u003eSoluble in water, DMSO, and ethanol.\u003c\/dd\u003e\n\u003cdt\u003eStorage Condition\u003c\/dt\u003e\n\u003cdd\u003eStore at -20°C; protect from light and moisture.\u003c\/dd\u003e\n\u003cdt\u003eCondition\u003c\/dt\u003e\n\u003cdd\u003eSurplus\/second-hand; stored under manufacturer-recommended conditions. [Package Status: UNUSED_OR_SEALED.]\u003c\/dd\u003e\n\u003c\/dl\u003e\n\u003c\/section\u003e\n\u003csection class=\"wlb-applications\"\u003e\n\u003ch2\u003eApplications\u003c\/h2\u003e\n\u003cp\u003e17-DMAG is utilized in oncology research to induce the degradation of Hsp90 client proteins such as HER2, Akt, and Raf-1. It is frequently applied in cell culture assays to study apoptosis induction and in signal transduction research to observe protein folding interference.\u003c\/p\u003e\n\u003c\/section\u003e\n\u003csection class=\"wlb-sustainability\"\u003e\n\u003ch2\u003eSustainability\u003c\/h2\u003e\n\u003cp\u003eBy rehoming surplus lab products, this listing supports waste reduction and resource efficiency.\u003c\/p\u003e\n\u003c\/section\u003e\n\u003csection class=\"wlb-responsible\"\u003e\n\u003ch3\u003eResponsible use \u0026amp; safety\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eRequire training\/authorization before use.\u003c\/li\u003e\n\u003cli\u003eInspect before operation; do not use if safety features are compromised.\u003c\/li\u003e\n\u003cli\u003eFollow manufacturer's manual for operation and maintenance.\u003c\/li\u003e\n\u003cli\u003eDecontaminate surfaces and dispose of chemical waste according to local institutional protocols.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/section\u003e\n\u003c\/article\u003e","brand":"Enzo Biochem","offers":[{"title":"L19064 \/ 1 mg \/ Unit \/ New — Unopened (Sealed)","offer_id":53878138372423,"sku":"ALX-380-110-M001","price":38.75,"currency_code":"USD","in_stock":true},{"title":"Lot NO 3-M11231X \/ 1 mg \/ Unit \/ New — Unopened (Sealed)","offer_id":53878138405191,"sku":"BML-EI337-0001-US","price":53.75,"currency_code":"USD","in_stock":true}],"url":"https:\/\/checkout.wasteless.bio\/en-us\/products\/enzo-biochem-17-dmag-us","provider":"Wasteless Bio","version":"1.0","type":"link"}