{"product_id":"enzo-biochem-rp-8-br-cgmps-2-us","title":"Enzo Biochem Rp-8-Br-cGMPS-2","description":"\u003carticle class=\"wlb-product\" itemscope itemtype=\"https:\/\/schema.org\/Product\"\u003e\n\u003cheader class=\"wlb-header\"\u003e\n\u003ch2 class=\"wlb-title\" itemprop=\"name\"\u003eEnzo Biochem Rp-8-Br-cGMPS-2\u003c\/h2\u003e\n\u003cp class=\"wlb-meta\"\u003eby \u003cspan class=\"wlb-brand\" itemprop=\"brand\"\u003eEnzo Biochem\u003c\/span\u003e · SKU \u003cspan class=\"wlb-sku\" itemprop=\"sku\"\u003eRp-8-Br-cGMPS-2\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/header\u003e\n\u003csection class=\"wlb-overview\"\u003e\n\u003ch2\u003eOverview\u003c\/h2\u003e\n\u003cp\u003eRp-8-Br-cGMPS is a potent and metabolic-stable sulfur-modified analog of cyclic GMP. It functions as a lipophilic inhibitor of cGMP-dependent protein kinase (PKG), specifically targeting PKG type I and II by competing with cGMP for binding sites without activating the enzyme.\u003c\/p\u003e\n\u003c\/section\u003e\n\u003csection class=\"wlb-highlights\"\u003e\n\u003ch2\u003eHighlights\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eHighly lipophilic membrane-permeant properties for efficient cellular uptake.\u003c\/li\u003e\n\u003cli\u003eIncreased metabolic stability against cyclic nucleotide phosphodiesterases (PDEs).\u003c\/li\u003e\n\u003cli\u003eEffective competitive inhibition of cGMP-dependent protein kinases I and II.\u003c\/li\u003e\n\u003cli\u003ePhosphorothioate modification ensures resistance to enzymatic degradation.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/section\u003e\n\u003csection class=\"wlb-ataglance\"\u003e\n\u003ch2\u003eAt-a-glance\u003c\/h2\u003e\n\u003cdl\u003e\n\u003cdt\u003eCapabilities\u003c\/dt\u003e\n\u003cdd\u003eCompetitive inhibition of PKG I and PKG II; PDE resistance.\u003c\/dd\u003e\n\u003cdt\u003eForm\u003c\/dt\u003e\n\u003cdd\u003eLyophilized solid\u003c\/dd\u003e\n\u003cdt\u003eRecommended Applications\u003c\/dt\u003e\n\u003cdd\u003eSignal transduction studies, vascular smooth muscle research, neurobiology, and ion channel modulation assays.\u003c\/dd\u003e\n\u003cdt\u003eCondition\u003c\/dt\u003e\n\u003cdd\u003eSurplus\/second-hand; stored under manufacturer-recommended conditions. \u003c\/dd\u003e\n\u003c\/dl\u003e\n\u003c\/section\u003e\n\u003csection class=\"wlb-applications\"\u003e\n\u003ch2\u003eApplications\u003c\/h2\u003e\n\u003cp\u003eUtilized in cardiovascular research to study nitric oxide and cGMP-mediated signaling pathways in smooth muscle cells. It is also applied in neuroscience to investigate the role of PKG in synaptic plasticity and long-term depression (LTD).\u003c\/p\u003e\n\u003c\/section\u003e\n\u003csection class=\"wlb-sustainability\"\u003e\n\u003ch2\u003eSustainability\u003c\/h2\u003e\n\u003cp\u003eBy rehoming surplus lab products, this listing supports waste reduction and resource efficiency.\u003c\/p\u003e\n\u003c\/section\u003e\n\u003csection class=\"wlb-responsible\"\u003e\n\u003ch3\u003eResponsible use \u0026amp; safety\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eRequire training\/authorization before use.\u003c\/li\u003e\n\u003cli\u003eInspect before operation; do not use if safety features are compromised.\u003c\/li\u003e\n\u003cli\u003eFollow manufacturer's manual for operation and maintenance.\u003c\/li\u003e\n\u003cli\u003eEquipment-specific guidance (e.g., keep airflow clear, replace filters regularly, decontaminate after use).\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/section\u003e\n\u003c\/article\u003e","brand":"Enzo Biochem","offers":[{"title":"5 µmol \/ Unit \/ New - Unopened (Sealed)","offer_id":53870966604103,"sku":"BLG-B005-05","price":110.5,"currency_code":"USD","in_stock":true},{"title":"500 µg \/ Unit \/ New - Unopened (Sealed)","offer_id":53870966636871,"sku":"BML-CN216-0500-US","price":57.75,"currency_code":"USD","in_stock":true},{"title":"10 µmol \/ Unit \/ New - Unopened (Sealed)","offer_id":53870966669639,"sku":"BLG-B006-10","price":43.75,"currency_code":"USD","in_stock":true}],"url":"https:\/\/checkout.wasteless.bio\/en-us\/products\/enzo-biochem-rp-8-br-cgmps-2-us","provider":"Wasteless Bio","version":"1.0","type":"link"}